Ccnd2 proliferation
WebApr 10, 2024 · The GRN revealed the cell cycle genes CCND2 and MCM5 as targets of PGR/AR signaling in childhood β cells (Figures 7 D and 7E). To test whether AR receptor activation could induce β cell proliferation, we treated SC-islets with dihydrotestosterone (DHT) during two different time windows of SC-islet differentiation and quantified relative … WebMar 1, 2013 · CCND2-deficient female mice are sterile owing to the inability of granulosa cells to proliferate and to preantral follicle growth arrest. FSH rapidly promotes a modest increase in Ccnd2 mRNA expression in granulosa cells [ 14, 15 ], while FSH β-null or FSH receptor-deficient mice exhibit decreased Ccnd2 mRNA level [ 2, 4 ].
Ccnd2 proliferation
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WebMar 18, 2024 · Third, tumours originating from distinct cellular lineages use different interphase CDKs as their primary driver of proliferation 10,11,12. ... CCND2 is a direct target gene of MYC 68; (4) ...
WebJun 20, 2024 · Although CCND2 P281 variants did not confer growth factor independence in the Ba/F3 model, past work had demonstrated a role for CCND2 in cytokine-mediated proliferation of bone marrow progenitor ... WebIn many studies, inhibition of CCND2 had been shown to hinder NSCLC proliferation and metastasis. 37–39 Further experiments revealed that the anti-cancer effect of miR-1248 in NSCLC could be reversed by CCND2 overexpression, indicating that miR-1248 targeted CCND2, an oncogene, to inhibit NSCLC progression. Additionally, the positive ...
WebMar 29, 2024 · Clinical resource with information about CCND2, Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three … WebJan 1, 2024 · Murine CCND2 promoter contains an enhancer complex at −1220 to −1191 bp, which has Sp1 and STAT5 binding sites. Sp1 and another unidentified factor bind …
WebAug 12, 2024 · CCND2 as a member of the cell cycle family, its abnormal expression may lead to abnormal cell proliferation. Studies have found that CCDN2 is abnormally expressed in a variety of tumor tissues, such as cervical cancer [ 27 ], gastric cancer [ 28 ], non-small cell lung cancer [ 29 ], and prostate cancer [ 30 , 31 ].
WebNov 25, 2024 · To determine how the expression levels of Ccnd2, Dnmt1, Tet2, and Lhcgr were regulated in granulosa cells during follicular development, granulosa cells were … github nomadcodersWebApr 24, 2024 · CCND2 and P27 are maintained in GCs of primordial follicles but decrease as follicles initiate growth. ( A) Immunofluorescent localisation of CCND2 (red) in the prepubertal mouse ovary. High... furan fatty acidWebMay 15, 2024 · Our research indicates that LINC00473/miR-16-5p/CCND2 axis plays a role in the proliferation of GC and modulates AQP3 to influence GC cell metastasis, making it a potential therapeutic target... github nodemcuWebJan 5, 2024 · Methods and results: Human CCND2 was delivered to hiPSCs via lentiviral-mediated gene transfection. In cultured cells, markers for cell cycle activation and … github no issues tabWebCyclin D2 (CCND2) belongs to the D-type cyclins family and has important roles in cell cycle regulation, differentiation, and malignant transformation. To establish the utility of … fur and wool coatWebUpregulation of miR-1297 and downregulation of CCND2 reduced the proliferation and metastasis potential of SW480 cells, but did not affect the apoptotic process. In addition, miR-1297 regulated CCND2 function by directly binding to the promoter sequence of the CCND2 gene, which would block CCND2-related signaling at the transcription level. furan fatty acid supplementsWebApr 14, 2010 · A dual-luciferase reporter assay demonstrated that the 3'UTR of E2F2 and CCND2 were directly bound to let-7a and western blotting analysis further indicated that let-7a down-regulated the expression of E2F2 and CCND2. Our xenograft models of prostate cancer confirmed the capability of let-7a to inhibit prostate tumor development in vivo. github noname